EWOC: Interactive tool for Designing and Conducting Dose Finding Trials in Cancer

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EWOC is a Bayesian adaptive dose finding design that produces consistent sequences of doses while controlling the probability that patients are overdosed. EWOC was the first dose-finding procedure to directly incorporate the ethical constraint of minimizing the chance of treating patients at unacceptably high doses. Its defining property is that the expected proportion of patients treated at doses above the maximum tolerated dose (MTD) is equal to a specified value α, the feasibility bound. This value is selected by the clinician and reflects his/her level of concern about overdosing. Among designs with this defining property, EWOC minimizes the average amount by which patients are underdosed. This means that EWOC approaches the MTD as rapidly as possible, while keeping the expected proportion of patients overdosed less than the value α. As a trial progresses, the dose sequence defined by EWOC approaches the MTD (i.e., the sequence of recommended doses converges in probability to the MTD). Eventually, all patients beyond a certain time would be treated at doses sufficiently close to the MTD.

Authors :
Andre’ Rogatko, PhD [email]
Mourad Tighiouart, PhD [email]
Galen Cook-Wiens, MS [email]
Quanlin Li, MS [email]

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